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Purpose
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A potent and selective G9a/GLP histone lysine methyltransferase inhibitor
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Characteristics
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A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
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Formula
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C₁₉H₂₇N₃O₂
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Permeability
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Cell-permeable
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Solubility
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DMSO (>25 mg/ml)
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