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Purpose
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A potent inhibitor of class A and C serine β-lactamases, including KPC carbapenemases
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Characteristics
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Avibactam (NXL104) is a potent inhibitor of class A and C serine β-lactamases, including KPC carbapenemases. NXL104 quantitatively inhibits BlaC, the only chromosomally encoded β-lactamase from Mycobacterium tuberculosis, by forming a carbamyl adduct with the enzyme.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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sodium;[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] sulfate; NXL104
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Formula
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C₇H₁₀N₃NaO₆S
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Permeability
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Cell-permeable
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Solubility
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H₂O (>4.0 mg/ml)
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