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Purpose
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A multi-targeted tyrosine kinase inhibitor
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Characteristics
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Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC₅₀ values of 10 nM, 40 nM and 81 nM, respectively. It also disrupts DNA repair likely through suppression of Homologous Recombination protein Rad51.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide; MP-470; HPK56
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Formula
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C₂₃H₂₁N₅O₃S
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Permeability
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Cell-permeable
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Solubility
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DMSO (>30 mg/ml)
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