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  • 产品名称：Altiratinib

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  • 产品厂商：Biovision
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简单介绍：
Altiratinib
详情介绍：
Purpose A highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases
Characteristics Altiratinib is a selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. It effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Through its balanced inhibitory potency versus MET, TIE2, and VEGFR2, altiratinib inhibits three major evasive (re)vascularization and resistance pathways (HGF, ANG, and VEGF) and blocks tumor invasion and metastasis. Displays blood-brain barrier penetration.
Purity ≥ 98 % by HPLC
Chemical Name N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; DCC-2701
Formula C₂₆H₂₁F₃N₄O₄
Permeability Cell-permeable
Solubility DMSO (>30 mg/ml)
Molecular Weight 510.46 g/mol
CAS-No 1345847-93-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months