|
Purpose
|
A potent microtubule polymerization inhibitor
|
|
Characteristics
|
ABT751 is a potent inhibitor of microtubule polymerization. It binds to the colchicine- on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.
|
|
Purity
|
≥ 98 % by HPLC
|
|
Chemical Name
|
N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
|
|
Formula
|
C₁₈H₁₇N₃O₄S
|
|
Permeability
|
Cell-permeable
|
|
Solubility
|
DMSO (>30 mg/ml) or EtOH (>5 mg/ml)
|
