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Purpose
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A selective and competitive androgen receptor (AR) inhibitor
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Characteristics
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ARN-509 is a selective and competitive androgen receptor (AR) inhibitor (IC₅₀ = 16 nM). ARN-509 selectively binds the androgen receptor and impairs its nuclear translocation and DNA binding to androgen response elements useful for prostate cancer treatment.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide
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Formula
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C₂₁H₁₅F₄N₅O₂S
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Permeability
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Cell-permeable
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Solubility
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DMSO (>5 mg/ml)
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