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Purpose
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A potent, and ATP-competitive inhibitor of ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase)
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Characteristics
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ASP-3026 is a potent, and ATP-competitive inhibitor of ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase) with IC₅₀ value of 3.5 nM. It also inhibits ROS (IC₅₀ = 8.9 nM) and ACK (IC₅₀ = 5.8 nM). ASP3026 has been shown to overcome Crizotinib (Cat. No. 1934) resistance in non-small cell lung cancer.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
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Formula
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C₂₉H₄₀N₈O₃S
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Permeability
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Cell-permeable
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Solubility
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DMSO
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