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Purpose
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A potent and selective mGluR5 receptor PAM (positive allosteric modulator)
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Characteristics
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ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC₅₀ = 0.17 μm, with no effect on other mGluR subtypes. ADX-47273 elevates extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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(S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
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Formula
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C₂₀H₁₇F₂N₃O₂
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Permeability
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Cell-permeable
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Solubility
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DMSO (>30 mg/ml)
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