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Purpose
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A highly potent MDM2 inhibitor
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Characteristics
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AMG232 is a highly potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC₅₀ = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED₅₀ = 9.1 mg/kg).
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Purity
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≥ 98 % by HPLC
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Chemical Name
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2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
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Formula
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C₂₈H₃₅Cl₂NOS
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Permeability
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Cell-permeable
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Solubility
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DMSO (>5 mg/ml)
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