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  • 产品名称：Poziotinib

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  • 产品厂商：Biovision
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简单介绍：
Poziotinib
详情介绍：
Characteristics

PubChem CID: 25127713
Molecular Formula: C₂₃H₂₁Cl₂FN₄O₃
Cell Premeable: Yes

Salt form: No

Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.

Smiles: COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C

InChi: InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

Inchi Key: LPFWVDIFUFFKJU-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one; HM781-36B; NOV120101
Formula C₂₃H₂₁Cl₂FN₄O₃
Permeability Cell-permeable
Background Synonyms: 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one, HM781-36B, NOV120101
Molecular Weight 491.34 g/mol
CAS-No 1092364-38-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months