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  • 产品名称：IOX2

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  • 产品厂商：Biovision
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简单介绍：
IOX2
详情介绍：
Characteristics

PubChem CID: 54685215
Molecular Formula: C₁₉H₁₆N₂O₅
Cell Premeable: Yes

IOX-2 is a potent, cell-permeable and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC₅₀ = 21 nM). It displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.

Smiles: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O

InChi: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)

Inchi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Formula C₁₉H₁₆N₂O₅
Permeability Cell-permeable
Background Synonyms: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Molecular Weight 352.34 g/mol
CAS-No 931398-72-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months