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Characteristics
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SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 µM) and HDAC3 (IC50 = 0.30 µM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. SBHA also enhances cytotoxicity induced by Oxaliplatin in the colorectal cancer cell lines.
Synonyms: Suberohydroxamic acid, suberic bis-hydroxamic acid, N,N'-dihydroxyoctanediamide
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