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  • 产品名称：IWP-3

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  • 产品厂商：Biovision
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简单介绍：
IWP-3
详情介绍：
Characteristics An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro (IC50= 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 µM).
Purity ≥ 98 %
Chemical Name Inhibitor of Wnt Production-3; 2-​[[3-​(4-​fluorophenyl)-​3,​4,​6,​7-​tetrahydro-​4-​oxothieno[3,​2-​ d]pyrimidin-​2-​yl]thio]-​N-​(6-​methyl-​2-​benzothiazolyl)-​acetamide
Formula C₂₂H₁₇FN₄O₂S₃
Permeability Cell-permeable
Molecular Weight 484.59 g/mol
CAS-No 687561-60-0
Restrictions For Research Use only
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for IWP-3 (ABIN1685724) IWP-3