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Characteristics
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A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50= 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 µM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.
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