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Characteristics
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A glucoside occurring in cotton and Hubiscus flowers that acts as a potent antimelanoma agent. Gossypin inhibits human melanoma cell proliferation, in vitro, in melanoma cell lines that harbors both BRAF-V600E kinase and CDK4 as well as in cells with BRAF wild-type allele. Gossypin inhibits the kinase activities of BRAF-V600E and CDK4, in vitro, possibly through direct binding with these kinases.
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