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Characteristics
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Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition ofRas-GAP and ERK1 with kDavalues of 98 and 212 nM, respectively.
Synonyms: N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo- 1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)- 3-(trifluoromethyl)benzamide, SC1
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