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  • 产品名称：24(S)-Hydroxycholesterol

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  • 产品厂商：Biovision
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简单介绍：
24(S)-Hydroxycholesterol
详情介绍：
Characteristics An important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain. It is an endogenous agonist of the nuclear receptor LXR. It has been shown to induce cell death in neuroblastoma cells, possibly via a necroptosis pathway. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORalpha and RORγ (Ki = 25 nM). 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications. It was also able to reduce A° production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.
Purity ≥ 99 % by HPLC
Chemical Name Cerebrosterol, Cholest-5-ene-3,24-diol, (24S)-24-Hydroxycholesterol, cholest-5-en-3beta,24S-diol
Formula C₂₇H₄₆O₂
Permeability Cell-permeable
Molecular Weight 402.66 g/mol
CAS-No 474-73-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 36 months
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