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Comment
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Synonyms:
Cyclic (Adenosine Monophosphate-Guanosine Monophosphate), cyclic GMP-AMP, c-(GpAp)
A potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-. Plays a role in bacterial chemotaxis and colonization
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