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  • 产品名称：EPZ-5676

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  • 产品厂商：Biovision
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EPZ-5676
详情介绍：
Characteristics A potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations.
Purity ≥ 98 % by HPLC
Chemical Name (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
Formula C₃₀H₄₂N₈O₃
Permeability Cell-permeable
Molecular Weight 562.71 g/mol
CAS-No 1380288-87-8
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 36 months
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image for EPZ-5676 (ABIN1685781) EPZ-5676