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Characteristics
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PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1alpha, VEGF and iNOS (IC50 values are 7.2, approx. 10 and 18.1 µM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.
Synonyms: 2-[(1-Methylpropyl)dithio]-1H-imidazole, IV-2
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