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Comment
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Synonyms:
Benzylpenicillin sodium salt
Penicillin G sodium is a member of the -lactam antibiotics. -Lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to -lactams is commonly due to cells containing plasmid encoded -lactamases. Penicillin can be used as a selective agent in several types of isolation media
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