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Characteristics
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Cell-permeable. AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC50 = 150 nM, hJNK2: IC50 = 220 nM and hJNK3: IC50 = 70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-alpha plasma levels induced by LPS in mice.
Synonyms: (Z)-2-(Benzo[d]thiazol-2(3H)-ylidene)-2-(2-((-(pyridine-3-yl)ethyl)amino)pyridine-4-yl)acetonitrile
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