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Characteristics
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A potent, selective, nonpeptidomimetic inhibitor of farnesyl protein transferase (FPT), an enzyme involved in protein processing (farnesylation) for signal transduction. Displays significant antitumor effects in vivo. Tipifarnib competitively inhibits the farnesylation of lamin B (IC50= 0.86 nM) and K-RasB (IC50= 7.9 nM) peptide substrates and inhibits the cell growth of ca. 75 % of a panel of 53 human tumor cell lines tested.
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