产品详情
所在位置: 首页> 产品目录> 辅助试剂>
查看大图

  • 产品名称：AGI-5198

  • 产品型号：
  • 产品厂商：Biovision
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
AGI-5198
详情介绍：
Characteristics A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC50values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC50s > 100 µM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9 me3 and expression.
Purity ≥ 98 % by HPLC
Chemical Name N-​[2-​(cyclohexylamino)-​1-​(2-​methylphenyl)-​2-​oxoethyl]-​N-​(3-​fluorophenyl)-​2-​methyl-​1H-​imidazole-​1-​acetamide; IDH-C35
Formula C₂₇H₃₁FN₄O₂
Permeability Cell-permeable
Molecular Weight 462.56 g/mol
CAS-No 1355326-35-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for AGI-5198 (ABIN1685757) AGI-5198