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Characteristics
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BIBF1120 is a triple angiokinase inhibitor. It blocks signaling through vascular endothelial growth factor receptors (VEGFR, IC50 values of 13 to 34 nM), platelet-derived growth factor receptors (PDGFR, IC50 values of 59 to 65 nM), and fibroblast growth factor receptors (FGFR, IC50 values of 37 to 610 nM).
Synonyms: (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1- yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6- carboxylate
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