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Characteristics
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Cell-permeable. The active enantiomer of (±)-Blebbistatin (ABIN1685823). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50= 0.5-5.0 µM), while weakly inhibiting smooth muscle myosin (IC50= 80 µM). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.
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