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Characteristics
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Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC50 value of 2 nM. Also acts as a farnesyl diphosphate synthase inhibitor (IC50 = 460 nM) and CD45 protein tyrosine phosphatase inhibitor.
Synonyms: Sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid, trihydrate, MK-217, Fosamax
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