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Characteristics
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Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC50 = 33 nM). It inhibits p110alpha at higher concentration (IC50 = 3 µM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA.YM-201636 also blocks retroviral exit by budding from cells.
Synonyms: 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3,Ä≤2,Ä≤:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide
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