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Characteristics
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An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IkappaB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
Synonyms: 1-Thio-beta-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, SKF39162
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