|
Characteristics
|
Cell-permeable. A selective, ATP-competitive inhibitor of PI3K+ with IC50 values of 0.25, > 20, > 20, and 4.5 µM for the human recombinant γ, delta, beta, and alpha isoforms, respectively. AS 604850 inhibits MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduces RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.
|
