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Characteristics
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DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate dehydrogenase) in a dose-dependent manner with EC50 of 4 µm. However, DHEA does not inhibit the enzymatic activity of PGD (6-phosphogluconate dehydrogenase), the second enzyme in the pentose phosphate pathway.
Synonyms: 5-Dehydroepiandrosterone, Dehydroisoandrosterone, Prasterone
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