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Characteristics
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An immunosuppressant and a potent inhibitor of NF-kappaB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-gamma, TNF-alpha, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-kappaB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
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