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Characteristics
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Cell permeable. A potentinhibitor of gamma-secretase (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). It reduces Abeta levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoidbodies independent of sonic hedgehog (shh) signaling.
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