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  • 产品名称：ImatinibMesylate(CGP-57148B,STI-571)

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  • 产品厂商：Biovision
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简单介绍：
ImatinibMesylate(CGP-57148B,STI-571)
详情介绍：
Characteristics An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC50 = 0.5 nM), phosphorylation of a fusion protein (IC50 = 30 nM), and viability of BaF3 cells expressing Rhe-PDGFRalpha in the absence of IL-3 (IC50 = 0.17 nM).
Purity ≥ 99 % by HPLC
Chemical Name CGP-57148B, STI-571
Formula C₂₉H₃₁N₇O.CH₄SO₃
Permeability Cell-permeable
Molecular Weight 589.71 g/mol
CAS-No 220127-57-1
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for Imatinib Mesylate (CGP-57148B, STI-571) (ABIN628986) Imatinib Mesylate (CGP-57148B, STI-571)