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  • 产品名称：UNC0638

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  • 产品厂商：Biovision
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UNC0638
详情介绍：
Characteristics Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of < 15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.
Purity ≥ 98 % by HPLC
Chemical Name 2-​Cyclohexyl-​6-​methoxy-​N-​[1-​(1-​methylethyl)-​4-​piperidinyl]-​7-​[3-​(1-​pyrrolidinyl)propoxy]-​4-​quinazolinamine
Formula C₃₀H₄₇N₅O₂
Permeability Cell-permeable
Molecular Weight 509.72 g/mol
CAS-No 1255580-76-7
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for UNC0638 (ABIN629336) UNC0638