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Characteristics
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Cell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin homology (PH) domain binding to PIP3 and facilitates Akt ubiquitination. Due to its dual inhibitory activity, SC66 displays a more effective growth suppression of transformed cells that contain a high level of Akt signaling, compared with other inhibitors of PIP3/Akt pathway.
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