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Characteristics
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Present as an active principle in the plant Magnolia grandiflora. Displays anxiolytic, antithrombotic, anti-tumor properties, etc. modulates the NF-kappaB activation pathway, an upstream effector VEGF, COX-2, and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides.
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