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  • 产品名称：FK-866

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  • 产品厂商：Biovision
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简单介绍：
FK-866
详情介绍：
Characteristics Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50 = approx. 1 nM).
Purity ≥ 98 % by NMR
Chemical Name N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Formula C₂₄H₂₉N₃O₂
Permeability Cell-permeable
Molecular Weight 391.51 g/mol
CAS-No 658084-64-1
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for FK-866 (ABIN629301) FK-866