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  • 产品名称：Celastrol

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  • 产品厂商：Biovision
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简单介绍：
Celastrol
详情介绍：
Characteristics Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50 = 40 nM for IL-1beta and IL-1alpha, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-alpha).Suppresses nitric oxide (NO) production (IC50 = 230 nM) and LPS-induced NF-kappaB activation (IC50 = 270 nM).Inhibits chymotrypsin-like activity of 20S proteasome (IC50 = 2.5 µM) and lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM).
Purity ≥ 98 % by TLC
Chemical Name (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Formula C₂₉H₃₈O₄
Permeability Cell-permeable
Molecular Weight 450.61 g/mol
CAS-No 34157-83-0
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for Celastrol (ABIN629348) Celastrol