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Characteristics
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A slow-releasing, water-soluble hydrogen sulfide (H,ÇÇS) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of variousproinflammatory mediators (such as IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
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