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Characteristics
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Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). In vitro, discriminates between Ca2+-dependent and -independent isoforms of PKC, selectively inhibits PKCalpha and PKCbeta1 (IC50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKCdelta, -epsilon, or -zeta (IC50 > 3 µM).
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