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Comment
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Synonyms:
1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
A potent and selective DOT1L inhibitor (IC = 0. 3 nM in a radioactive enzyme assay), >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79 dimethylation with cellular IC of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells
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