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  • 产品名称：SunitinibMalate(Sutent)

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  • 产品厂商：Biovision
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简单介绍：
SunitinibMalate(Sutent)
详情介绍：
Characteristics Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC50 of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC50 of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC50 = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC50 value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC50 = 2 nM).
Purity ≥ 99 % by HPLC
Chemical Name Sunitinib Maleate, SU-11248, Sutent, PHA-290940AD, PNU-290940AD
Formula C₂₂H₂₇FN₄O₂.C₄H₆O₅
Permeability Cell-permeable
Molecular Weight 532.56 g/mol
CAS-No 341031-54-7
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Powder
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for Sunitinib Malate (Sutent) (ABIN412205) Sunitinib Malate (Sutent)