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  • 产品名称：ABT-263

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  • 产品厂商：Biovision
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简单介绍：
ABT-263
详情介绍：
Purpose A potent, small molecule Bcl-2 family protein inhibitor
Characteristics White to off-white solid
Molecular formular: C45H55ClF3N5O6S3
Purity ≥ 98 % by HPLC
Chemical Name (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide; Navitoclax
Formula C₄₅H₅₅ClF₃N₅O₆S₃
Permeability Cell-permeable
Molecular Weight 974.61 g/mol
CAS-No 923564-51-6
Comment

Synonyms:
(R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide, Navitoclax
A potent, small molecule Bcl-2 family protein inhibitor (Ki's of <1 nm="" l="" for="" bcl-2,="" bcl-xl="" and="" bcl-w).="" displays="" anticancer="" properties.="" selectively="" binds="" to="" apoptosis="" suppressor="" proteins="" bcl-xl,="" bcl-w="" prevents="" their="" binding="" the="" apoptotic="" effectors="" bax="" bak="" proteins,="" which="" may="" trigger="" in="" tumor="" cells="" overexpressing="" bcl-w<="" p="">

Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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image for ABT-263 (ABIN1889139) ABT-263