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  • 产品名称：UNC1999

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  • 产品厂商：Biovision
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简单介绍：
UNC1999
详情介绍：
Purpose A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor
Characteristics White to off-white solid
Molecular formular: C33H43N7O2
Purity ≥ 98 % by HPLC
Chemical Name 1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Formula C₃₃H₄₃N₇O₂
Permeability Cell-permeable
Molecular Weight 569.74 g/mol
CAS-No 1431612-23-5
Comment

Synonyms:
1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC = 2 nM). UNC1999 is >1000-fold selective for other HMTs except EZH1 (22-fold selectivity). It inhibits H3K27 methylation in MCF10A cells with an IC of 124 nM as measured by immunofluorescence
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for UNC1999 (ABIN1889136) UNC1999