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  • 产品名称：JumonjiHDMInhibitor,PBIT

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  • 产品厂商：Biovision
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简单介绍：
JumonjiHDMInhibitor,PBIT
详情介绍：
Purpose PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM)
Characteristics PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B.
Purity ≥ 98 % by HPLC
Chemical Name 2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
Formula C₁₄H₁₁NOS
Permeability Cell-permeable
Solubility DMSO (approx. 50 mg/mL)
Molecular Weight 241.31 g/mol
CAS-No 2514-30-9
Comment

PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC of about 3 m in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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