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Purpose
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A multi-targeted c-Abl, JAK2, Aurora A and B inhibitor
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Characteristics
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A pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM) and Abl/T315I (IC₅₀ = 4 nM).
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Purity
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≥ 98 % by HPLC
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Chemical Name
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1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
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Formula
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C₁₉H₂₃N₇O₂
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Permeability
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Cell-permeable
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Solubility
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DMSO (>70 mg/ml) or EtOH (>25 mg/ml)
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