|
Purpose
|
A potent Brutons Tyrosine Kinase (BTK) inhibitor
|
|
Characteristics
|
A potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC50= 0.5 nM) with potential antineoplastic activity. It.binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK.
|
|
Purity
|
≥ 98 % by HPLC
|
|
Chemical Name
|
2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; Ibrutinib; CRA-032765
|
|
Formula
|
C₂₅H₂₄N₆O₂
|
|
Permeability
|
Cell-permeable
|
|
Solubility
|
DMSO (> 80 mg/mL)
|
