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Purpose
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A potent NAALADase inhibitor
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Characteristics
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PMPA is a highly potent and selective inhibitor of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase or glutamate carboxypeptidase II or GCPII) with a Ki value of 275 pM. Displays robust neuroprotective activity in both in vitro and in vivo models of ischemia.
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Purity
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≥ 95 % by NMR
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Chemical Name
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2-(Phosphonomethyl)pentane-1,5-dioic acid; PMPA
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Formula
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C₆H₁₁O₇P
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Permeability
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Cell-permeable
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Solubility
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H2O (> 20 mg/mL)
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