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  • 产品名称：3-DeazaneplanocinAhydrochloride

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  • 产品厂商：Biovision
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简单介绍：
3-DeazaneplanocinAhydrochloride
详情介绍：
Purpose A lysine methyltransferase EZH2 (KMT63) inhibitor.
Characteristics White to off-white solid
Molecular formular: C12H14N4O3. HCl
Purity ≥ 98 % by HPLC
Chemical Name DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol hydrochloride
Formula C₁₂H₁₄N₄O₃. HCl
Permeability Cell-permeable
Molecular Weight 298.73 g/mol
CAS-No 120964-45-6
Comment

Synonyms:
DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol hydrochloride
A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for 3-Deazaneplanocin A hydrochloride (ABIN1889114) 3-Deazaneplanocin A hydrochloride